With Wisdom Comes Vexation and Anguish

How True This Seems To Be

Ecclesiastes 1:18 
For in much wisdom is much grief: and he that increaseth knowledge increaseth sorrow.

wisdom 

חָכמָה chokmah (chok-maw') n-f.

wisdom (in a good sense).

-this is more like being skilled and possessing wit. 

grief

 כַּעַס ka`ac (kah'-as) n-m.

   כַּעַשׂ ka`as (kah'-as) [in Job]

vexation.

knowledge

 דַּעַת da`ath (dah'-ath) n-e.

knowledge.

-this is more informational such as being aware of something is to have knowledge on that.

sorrow

מַכְאֹב mak'ob (mak-oɓe') n-m.

   מַכְאוֹב mak'owb (mak-oɓe') [sometimes]

   מַכְאֹבָה mak'obah (mak-o-ɓaw') [feminine, Isaiah 53:3]

1. anguish.

2. (figuratively) affliction.

root from word of meaning: grief, pain, sorrow